SIMPLE Antibody™ platform sources V-regions from the immune system of "outbred" llamas (i.e. that each animal has a different genetic background). The outbred nature explains why each llama is able to generate a unique, individual immune response, providing a wide array of antibody V-regions against potentially any target of interest. This results in an enhanced range of potential targets and antibody profiles that can be generated through argenx's platform. SIMPLE Antibody™ provides the ideal starting point for antibody drug discovery, enabling development with maximum speed and efficiency.
MAbs 2015, Klarenbeek et al.