Innovation

The Science of Collaboration

We bring our antibody engineering expertise to pioneering researchers with the intent to advance immunology breakthroughs into differentiated medicines for patients.

Through collaboration, we have a common purpose and can accelerate discovery processes to bring solutions to patients who need them.

We know that together we are better.

Immunology Innovation Program (IIP)

The Immunology Innovation Program (IIP) is a core business strategy of argenx connecting the specialized insight into disease and target biology of our external scientific and academic collaborators with our unparalleled experience as antibody engineers.

Co-creation has led to a deep pipeline of highly differentiated product candidates.

Through the IIP, we hope to together transcend breakthrough research and publications to our ultimate and unifying mission of creating new potential treatment options for patients.

Immunology Innovation Program (IIP)

The Immunology Innovation Program (IIP) is a core business strategy of argenx connecting the specialized insight into disease and target biology of our external scientific and academic collaborators with our unparalleled experience as antibody engineers.

Co-creation has led to a deep pipeline of highly differentiated product candidates.

Through the IIP, we hope to together transcend breakthrough research and publications to our ultimate and unifying mission of creating new potential treatment options for patients.

Antibody Engineering

Innovation and co-creation are at the core of our strategy. We integrate our unique antibody engineering capabilities with the deep disease and target biology expertise of our collaborators. By innovating at the discovery level, we have built a broad pipeline of differentiated potential immunology solutions to offer patients.

We innovate at both the variable region or V region (where antigens and foreign proteins are recognized) and the constant region or Fc region (where antibodies modulate other cells in the immune system):

 Antibody

V region

innovation-1 FC region

Technology Role

Suite of Technologies

Unlock novel and complex targets

SIMPLE Antibody™ Platform

SIMPLE Antibody™ is argenx's proprietary platform designed to source V regions from the immune system of "outbred" llamas.

Modulate immune response

Three Fc engineering technologies (NHANCE®, ABDEG™ and POTELLIGENT®) are intended to expand the therapeutic index of argenx antibodies.

Unique suite of technologies enables development of differentiated product candidates against novel targets

An Innovation Ecosystem

"Stepping into these strategic, academic, industry collaborations. This is a wonderful
ecosystem that we are creating, by bringing that expertise together."

— Prof. Bart Lambrecht

Case Studies

 Structuring our pipeline growth

Efgartigimod

Target:
FcRn

Efgartigimod (ARGX-113) was designed as a human IgG1 antibody Fc-fragment, a natural ligand of the neonatal Fc receptor (FcRn). FcRn is known to extend half-life and availability of pathogenic IgG antibodies.

Efgartigimod has been engineered for increased affinity to FcRn and was built in collaboration with Prof. E. Sally Ward, Ph.D. who is a pioneer of FcRn biology.

ARGX-118

Target:
Galectin-10

ARGX-118 was designed as a highly differentiated antibody against Galectin-10, the protein of Charcot-Leyden crystals, which are implicated as a major contributor to severe asthma and to the persistence of mucus plugs.

ARGX-118 was built in collaboration with Prof. Bart Lambrecht, M.D., Ph.D. who identified the first novel airway inflammation target in decades.

ARGX-115

Target:
GARP

ARGX-115 (now ABBV-151) was designed as a humanized monoclonal antibody inhibitor of GARP- TGF-β1 and is in development by AbbVie for the treatment of cancer.

ARGX-115 was built in collaboration with Prof. Sophie Lucas, M.D., Ph.D. who has been a leader in checkpoint biology research since 1985.

Academic Collaborators

logo academic beruniversity

Bern University

logo Columbia University

Columbia University

logo Institut de Duve

Institut de Duve

logo Leiden University

Leiden University

logo Ludwig Cancer Research

Ludwig Cancer Research

logo National Jewish Health

National Jewish Health

logo Université Catholique de Louvain

Université Catholique de Louvain

logo Turin University

Turin University

logo University Of  Pennsylvania

University Of Pennsylvania

logo NYU School of Medicine

NYU School of Medicine

logo UT Southwestern

UT Southwestern

logo Flemish Institute for Biotechnology

Flemish Institute for Biotechnology

logo Utrecht University

Utrecht University

logo academic beruniversity

Bern University

logo Columbia University

Columbia University

logo Institut de Duve

Institut de Duve

logo Leiden University

Leiden University

logo Ludwig Cancer Research

Ludwig Cancer Research

logo National Jewish Health

National Jewish Health

logo Université Catholique de Louvain

Université Catholique de Louvain

logo Turin University

Turin University

logo University Of  Pennsylvania

University Of Pennsylvania

logo NYU School of Medicine

NYU School of Medicine

logo UT Southwestern

UT Southwestern

logo Flemish Institute for Biotechnology

Flemish Institute for Biotechnology

logo Utrecht University

Utrecht University

Partnering Opportunities

Deep relationships power the core of our innovation ecosystem, it is a system of co-creation.

The Immunology Innovation Program is based on mutual respect for the expertise that each partner brings. Our research collaborators bring unique knowledge of disease biology or a disease pathway. argenx can offer antibody engineering capabilities and a path to turn an immunology breakthrough into a clinical development candidate.

We together with our partners have the potential to create differentiated medicines for patients.

For more information on partnering opportunities, please contact BD@argenx.com

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